GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs477692 | 1 | rs479478 | chr10:131428959 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.48 | 2.06E-5 | Response to temozolomide |
| THYM | cis | rs8078723 | 1 | rs4794823 | chr17:38166265 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.52 | 1.73E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs8078723 | 1 | rs4794824 | chr17:38179290 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.12 | 1.23E-14 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs8078723 | 1 | rs4795412 | chr17:38150604 | GSDMA | chr17:38119226-38134019:+ | -0.89 | -9.76 | 5.45E-16 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs8078723 | 1 | rs4795415 | chr17:38157995 | GSDMA | chr17:38119226-38134019:+ | -0.89 | -9.76 | 5.45E-16 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs8078723 | 1 | rs4795416 | chr17:38158133 | GSDMA | chr17:38119226-38134019:+ | -0.89 | -9.76 | 5.45E-16 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs8078723 | 1 | rs4795418 | chr17:38164851 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.52 | 1.73E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs4803480 | 1 | rs4803480 | chr19:42066279 | CEACAM21 | chr19:42055886-42093196:+ | 0.64 | 8.65 | 1.29E-13 | Schizophrenia |
| THYM | cis | rs4821544 | 1 | rs4821544 | chr22:37258503 | NCF4 | chr22:37257030-37274058:+ | 0.47 | 7.08 | 2.51E-10 | Atopic dermatitis |
| THYM | cis | rs9876781 | 1 | rs4858793 | chr3:48415007 | TREX1 | chr3:48501186-48509043:+ | 0.31 | 4.84 | 4.98E-6 | Longevity |
| THYM | cis | rs9876781 | 1 | rs4858817 | chr3:48416756 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 4.48 | 2.04E-5 | Longevity |
| THYM | cis | rs2273 | 1 | rs4859413 | chr4:76898250 | NAAA | chr4:76831809-76862166:- | 0.46 | 4.92 | 3.56E-6 | Longevity |
| THYM | cis | rs2273 | 1 | rs4859581 | chr4:76906974 | NAAA | chr4:76831809-76862166:- | -0.46 | -4.92 | 3.56E-6 | Longevity |
| THYM | cis | rs2273 | 1 | rs4859582 | chr4:76907213 | NAAA | chr4:76831809-76862166:- | -0.46 | -4.92 | 3.56E-6 | Longevity |